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Compound Detail

CHEMBL4449608

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COc1cccnc1C1CCN(C2CCCN(c3nccnc3C)CC2)CC1

Basic Information

ChEMBL ID CHEMBL4449608
Phase Preclinical
Structure Type MOL
InChI Key APRFZDOURHFBPX-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

381.5
MW (Da)
3.43
ALogP
6
HBA
0
HBD
54.4
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H31N5O
MW 381.52
Aromatic Rings 2
Heavy Atoms 28
NP-Likeness -0.97

Activity Summary

EC50 2 meas. best 5.47

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M4
CHEMBL1821
EC50 5.47 5.46 3410.0 2

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31223452 10.1021/acsmedchemlett.9b00106 Muscarinic acetylcholine receptor M4 3

Data from ChEMBL 36 via Core Engine