Compound Detail
CHEMBL4454711
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Basic Information
| ChEMBL ID | CHEMBL4454711 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | GSOOYNWQKINCJY-DIVWUKMWSA-N |
| Parent Compound | CHEMBL4596542 |
| Active Moiety | CHEMBL4596542 |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
297.4
MW (Da)
0.28
ALogP
5
HBA
3
HBD
110.5
PSA (Ų)
0.65
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Cereblon isoform 4 CHEMBL3763007 | Ki | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Cereblon isoform 4 | Ki | = | 5000.0 | nM | 5.3 | Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense ... | 31251063 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31251063 | 10.1021/acs.jmedchem.9b00454 | Cereblon isoform 4 | 1 |
| 31251063 | 10.1021/acs.jmedchem.9b00454 | No relevant target | 1 |
| 31251063 | 10.1021/acs.jmedchem.9b00454 | Cereblon/Casein kinase I alpha | 1 |
| 31251063 | 10.1021/acs.jmedchem.9b00454 | Protein cereblon/Aiolos | 1 |
Data from ChEMBL 36 via Core Engine