Assay Detail
Binding
CHEMBL4366978
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MANT-uracil binding to wild-type Magnetospirillum gryphiswaldense CRBN isoform 4 by FRET assay
26
Total Activities
26
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Magnetospirillum gryphiswaldense |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Cereblon isoform 4 (CHEMBL3763007) ↗| Type | SINGLE PROTEIN |
| Organism | Magnetospirillum gryphiswaldense |
Publication
De-Novo Design of Cereblon (CRBN) Effectors Guided by Natural Hydrolysis Products of Thalidomide Derivatives.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 26 | 5.02 | 6.10 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL43452 | POMALIDOMIDE | 4.0 | 1 | 6.10 |
| CHEMBL848 | LENALIDOMIDE | 4.0 | 1 | 5.51 |
| CHEMBL4464143 | — | — | 1 | 5.40 |
| CHEMBL275661 | SUCCINIMIDE | -1.0 | 1 | 5.37 |
| CHEMBL468 | THALIDOMIDE | 4.0 | 1 | 5.36 |
| CHEMBL4454711 | — | — | 1 | 5.30 |
| CHEMBL475232 | — | — | 1 | 5.05 |
| CHEMBL4437349 | — | — | 1 | 5.05 |
| CHEMBL4589257 | — | — | 1 | 5.00 |
| CHEMBL4589159 | — | — | 1 | 4.96 |
| CHEMBL4455877 | — | — | 1 | 4.92 |
| CHEMBL4556836 | — | — | 1 | 4.92 |
| CHEMBL4563318 | — | — | 1 | 4.92 |
| CHEMBL4521923 | — | — | 1 | 4.70 |
| CHEMBL4561295 | — | — | 1 | 4.70 |
| CHEMBL4447985 | — | — | 1 | 4.70 |
| CHEMBL3763941 | — | — | 1 | 4.55 |
| CHEMBL4442722 | — | — | 1 | 4.44 |
| CHEMBL4472234 | — | — | 1 | 4.35 |
| CHEMBL4544710 | — | — | 1 | - |
| CHEMBL4451173 | — | — | 1 | - |
| CHEMBL4581801 | — | — | 1 | - |
| CHEMBL4437150 | — | — | 1 | - |
| CHEMBL4520346 | — | — | 1 | - |
| CHEMBL370441 | — | — | 1 | - |
| CHEMBL4454431 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL43452 | POMALIDOMIDE | Ki | = | 800.0 | nM | 6.10 |
| CHEMBL848 | LENALIDOMIDE | Ki | = | 3100.0 | nM | 5.51 |
| CHEMBL4464143 | — | Ki | = | 4000.0 | nM | 5.40 |
| CHEMBL275661 | SUCCINIMIDE | Ki | = | 4300.0 | nM | 5.37 |
| CHEMBL468 | THALIDOMIDE | Ki | = | 4400.0 | nM | 5.36 |
| CHEMBL4454711 | — | Ki | = | 5000.0 | nM | 5.30 |
| CHEMBL475232 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4437349 | — | Ki | = | 9000.0 | nM | 5.05 |
| CHEMBL4589257 | — | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4589159 | — | Ki | = | 11000.0 | nM | 4.96 |
| CHEMBL4455877 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL4556836 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL4563318 | — | Ki | = | 12000.0 | nM | 4.92 |
| CHEMBL4521923 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL4561295 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL4447985 | — | Ki | = | 20000.0 | nM | 4.70 |
| CHEMBL3763941 | — | Ki | = | 28000.0 | nM | 4.55 |
| CHEMBL4442722 | — | Ki | = | 36000.0 | nM | 4.44 |
| CHEMBL4472234 | — | Ki | = | 45000.0 | nM | 4.35 |
| CHEMBL4544710 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL4451173 | — | Ki | > | 99000.0 | nM | - |
| CHEMBL4581801 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL4437150 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL4520346 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL370441 | — | Ki | > | 40000.0 | nM | - |
| CHEMBL4454431 | — | Ki | > | 40000.0 | nM | - |