Compound Detail
CHEMBL4455300
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
NC(=O)CC[C@H](NC(=O)[C@@H]1CC[C@@H]2CCN(C(=O)CCN3CCC(C#Cc4cccc5c4CN(C4CCC(=O)NC4=O)C5=O)CC3)C[C@H](NC(=O)c3cc4cc(C(F)(F)P(=O)(O)O)ccc4[nH]3)C(=O)N21)C(=O)NC(c1ccccc1)c1ccccc1
Basic Information
| ChEMBL ID | CHEMBL4455300 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FDBBKBSMSHLUPL-RNJJLJFWSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
1199.2
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.44
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 6.44 | 6.44 | 360.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 360.0 | nM | 6.44 | Antiproliferative activity against human MOLM16 cells assessed as reduction in c... | 31747516 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Protein cereblon/STAT3 | 2 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Unchecked | 1 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | SU-DHL-1 | 1 |
Data from ChEMBL 36 via Core Engine