Compound Detail
CHEMBL4456833
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Basic Information
| ChEMBL ID | CHEMBL4456833 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JHMSCTXXWOJJDW-UHFFFAOYSA-N |
7
Targets
7
Activities
1
Assay Types
0
PK Parameters
7
Publications
0
Known Names
Molecular Properties
372.4
MW (Da)
3.28
ALogP
7
HBA
2
HBD
95.8
PSA (Ų)
0.71
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 7 meas. best 7.96
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | IC50 | 7.96 | 7.96 | 10.9 | 1 |
| MV4-11 CHEMBL613835 | IC50 | 6.97 | 6.97 | 107.0 | 1 |
| Z-138 CHEMBL4483276 | IC50 | 6.38 | 6.38 | 422.0 | 1 |
| Ramos CHEMBL614629 | IC50 | 6.01 | 6.01 | 986.0 | 1 |
| JeKo-1 CHEMBL4296445 | IC50 | 5.86 | 5.86 | 1390.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.41 | 5.41 | 3857.0 | 1 |
| RPMI-8226 CHEMBL614882 | IC50 | 5.13 | 5.13 | 7434.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 | IC50 | = | 10.95 | nM | 7.96 | Inhibition of recombinant human N-terminal GST-tagged CHK1 (M1 to T476 residues)... | 30986571 |
| MV4-11 | IC50 | = | 107.0 | nM | 6.97 | Inhibition of human MV411 cells incubated for 72 hrs by cellTiter 96 aqueous one... | 30986571 |
| Z-138 | IC50 | = | 422.0 | nM | 6.38 | Inhibition of human Z138 cells incubated for 72 hrs by cellTiter 96 aqueous one ... | 30986571 |
| Ramos | IC50 | = | 986.0 | nM | 6.01 | Inhibition of human Ramos cells incubated for 72 hrs by cellTiter 96 aqueous one... | 30986571 |
| JeKo-1 | IC50 | = | 1390.0 | nM | 5.86 | Inhibition of human JeKo1 cells incubated for 72 hrs by cellTiter 96 aqueous one... | 30986571 |
| Unchecked | IC50 | = | 3857.0 | nM | 5.41 | Inhibition of human Mino cells incubated for 72 hrs by cellTiter 96 aqueous one ... | 30986571 |
| RPMI-8226 | IC50 | = | 7434.0 | nM | 5.13 | Inhibition of human RPMI8226 cells incubated for 72 hrs by cellTiter 96 aqueous ... | 30986571 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30986571 | 10.1016/j.ejmech.2019.03.062 | Serine/threonine-protein kinase Chk1 | 1 |
| 30986571 | 10.1016/j.ejmech.2019.03.062 | RPMI-8226 | 1 |
| 30986571 | 10.1016/j.ejmech.2019.03.062 | Unchecked | 1 |
| 30986571 | 10.1016/j.ejmech.2019.03.062 | Ramos | 1 |
| 30986571 | 10.1016/j.ejmech.2019.03.062 | JeKo-1 | 1 |
| 30986571 | 10.1016/j.ejmech.2019.03.062 | MV4-11 | 1 |
| 30986571 | 10.1016/j.ejmech.2019.03.062 | Z-138 | 1 |
Data from ChEMBL 36 via Core Engine