Compound Detail
CHEMBL4458272
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4458272 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZKGQTSHJCCJMGL-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
374.4
MW (Da)
3.02
ALogP
4
HBA
2
HBD
88.4
PSA (Ų)
0.67
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 8.0 | 8.0 | 10.0 | 1 |
| Histone acetyltransferase KAT6A CHEMBL3774298 | IC50 | 7.96 | 7.96 | 11.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 10.0 | nM | 8.0 | Biochemical Assay: Active Moz protein was expressed as N-terminal fusion protein... | - |
| Histone acetyltransferase KAT6A | IC50 | = | 11.0 | nM | 7.96 | Inhibition of N-terminal NusA-fused His6-tagged human KAT6A (507 to 778 residues... | 32118427 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32118427 | 10.1021/acs.jmedchem.9b02071 | No relevant target | 2 |
| 32118427 | 10.1021/acs.jmedchem.9b02071 | Histone acetyltransferase KAT6A | 1 |
Data from ChEMBL 36 via Core Engine