Compound Detail
CHEMBL4458276
ENMETAZOBACTAM 💊 Approved Drug
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💊 Approved Drug
C[n+]1ccn(C[C@@]2(C)[C@H](C(=O)[O-])N3C(=O)C[C@H]3S2(=O)=O)n1
Basic Information
| ChEMBL ID | CHEMBL4458276 |
| Name | ENMETAZOBACTAM |
| Phase | Approved |
| Structure Type | MOL |
| InChI Key | HFZITXBUTWITPT-YWVKMMECSA-N |
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
3
Publications
5
Known Names
1
Indications
1
Mechanisms
Molecular Properties
314.3
MW (Da)
-3.43
ALogP
7
HBA
0
HBD
116.3
PSA (Ų)
0.42
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| First Approval | 2024 |
| Availability | Discontinued |
| Chirality | Single Enantiomer |
Mechanism of Action
| Mechanism | Action Type | Target | Direct | Efficacy |
|---|---|---|---|---|
| Bacterial beta-lactamase TEM inhibitor | INHIBITOR | Beta-lactamase TEM | ✓ | ✓ |
Indications
Bacterial Infections
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30288219 | 10.1039/C8MD00342D | Unchecked | 2 |
| 31663735 | 10.1021/acs.jmedchem.9b01279 | Escherichia coli | 1 |
| 31663735 | 10.1021/acs.jmedchem.9b01279 | Klebsiella pneumoniae | 1 |
Data from ChEMBL 36 via Core Engine