Compound Detail
CHEMBL4459308
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C[C@@H](O)[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](Cc2ccccc2)NC(=O)[C@@H](NC(=O)[C@@H](Cc2ccccc2)NC(=O)CN2CCN(CC(=O)O)CCN(CC(=O)O)CCN(CC(=O)O)CC2)CSSC[C@@H](C(=O)N[C@H](CO)[C@@H](C)O)NC1=O
Basic Information
| ChEMBL ID | CHEMBL4459308 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JROUKVAZUFLIQV-QFUARKCRSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
1405.7
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.99
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 6.99 | 6.99 | 103.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 4 | IC50 | = | 103.0 | nM | 6.99 | Inhibition of human SSTR4 by radioligand binding assay | 30503939 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30503939 | 10.1016/j.ejmech.2018.11.030 | Somatostatin receptor type 5 | 1 |
| 30503939 | 10.1016/j.ejmech.2018.11.030 | Somatostatin receptor type 4 | 1 |
Data from ChEMBL 36 via Core Engine