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Compound Detail

CHEMBL4459721

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COc1ncc(-c2ccc3ncnc(N[C@H]4CCCN(CCO)C4)c3c2)cc1C#N

Basic Information

ChEMBL ID CHEMBL4459721
Phase Preclinical
Structure Type MOL
InChI Key UHWXFKHHNZEFAK-SFHVURJKSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

404.5
MW (Da)
2.44
ALogP
8
HBA
2
HBD
107.2
PSA (Ų)
0.65
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C22H24N6O2
MW 404.47
Aromatic Rings 3
Heavy Atoms 30
NP-Likeness -1.37

Activity Summary

IC50 2 meas. best 8.33

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
CHEMBL3130
IC50 8.33 8.33 4.7 1
SU-DHL-6
CHEMBL4296496
IC50 5.69 5.69 2050.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
31434616 10.1016/j.bmc.2019.07.051 Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform 1
31434616 10.1016/j.bmc.2019.07.051 SU-DHL-6 1

Data from ChEMBL 36 via Core Engine