Compound Detail
CHEMBL4459764
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Basic Information
| ChEMBL ID | CHEMBL4459764 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BJPHSHCMKSGXGS-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
474.4
MW (Da)
4.36
ALogP
7
HBA
3
HBD
114.6
PSA (Ų)
0.49
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.84
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Death-associated protein kinase 1 CHEMBL2558 | IC50 | 4.84 | 4.84 | 14300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Death-associated protein kinase 1 | IC50 | = | 14300.0 | nM | 4.84 | Inhibition of human DAPK1 (1 to 363 residues) using KKLNRTLSFAEPG as substrate a... | 30445265 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30445265 | 10.1016/j.ejmech.2018.10.057 | Death-associated protein kinase 1 | 3 |
| 30445265 | 10.1016/j.ejmech.2018.10.057 | Macrophage colony-stimulating factor 1 receptor | 2 |
Data from ChEMBL 36 via Core Engine