Compound Detail
CHEMBL4460053
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CCCCC(NC(C)=O)C(=O)N[C@H]1CCC(=O)NCCCC[C@@H](C(N)=O)NC(=O)[C@H](Cc2c[nH]c3ccccc23)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](Cc2ccccc2)NC(=O)[C@H](Cc2cnc[nH]2)NC1=O
Basic Information
| ChEMBL ID | CHEMBL4460053 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ASWLQTJSLWJPAW-HRIBMNPLSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
1038.2
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 10.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Melanocortin receptor 4 CHEMBL259 | EC50 | 10.52 | 9.66 | 0.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Melanocortin receptor 4 | EC50 | = | 0.03 | nM | 10.52 | Agonist activity at human FLAG-tagged MC4R expressed in HEK293 cells assessed as... | 29669202 |
| Melanocortin receptor 4 | EC50 | = | 1.6 | nM | 8.8 | Agonist activity at human FLAG-tagged MC4R expressed in HTLA cells assessed as i... | 29669202 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29669202 | 10.1021/acs.jmedchem.8b00238 | Melanocortin receptor 4 | 2 |
Data from ChEMBL 36 via Core Engine