Compound Detail
CHEMBL4462073
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Basic Information
| ChEMBL ID | CHEMBL4462073 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MNKQUDROCZIINF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
348.3
MW (Da)
3.21
ALogP
4
HBA
0
HBD
51.0
PSA (Ų)
0.73
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B CHEMBL1904 | IC50 | 7.0 | 7.0 | 100.0 | 1 |
| Glutamate NMDA receptor; GRIN1/GRIN2B CHEMBL1907603 | IC50 | 6.84 | 6.84 | 145.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glutamate receptor ionotropic, NMDA 2B | IC50 | = | 100.0 | nM | 7.0 | Inhibition of Specific Binding to the Rat NR1/NR2B Receptor: The assay depends o... | - |
| Glutamate NMDA receptor; GRIN1/GRIN2B | IC50 | = | 145.0 | nM | 6.84 | Negative allosteric modulation of recombinant human GluN1a/GluN2B expressed in C... | 30891123 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30891123 | 10.1021/acsmedchemlett.8b00542 | ADMET | 2 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Glutamate NMDA receptor; GRIN1/GRIN2B | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Cytochrome P450 1A2 | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Cytochrome P450 2C19 | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Cytochrome P450 2C8 | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Cytochrome P450 2C9 | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Cytochrome P450 2D6 | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Cytochrome P450 3A4 | 1 |
| 30891123 | 10.1021/acsmedchemlett.8b00542 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine