Compound Detail
CHEMBL446269
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Basic Information
| ChEMBL ID | CHEMBL446269 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PTDHIIWRLMCNKG-LLVKDONJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
281.4
MW (Da)
1.43
ALogP
5
HBA
2
HBD
67.1
PSA (Ų)
0.74
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H4 receptor CHEMBL4468 | EC50 | 7.72 | 7.72 | 19.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H4 receptor | EC50 | = | 19.05 | nM | 7.72 | Antagonist activity at rat histamine H4 receptor expressed in HEK293 cells asses... | 18817367 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18817367 | 10.1021/jm800670r | Histamine H4 receptor | 2 |
Data from ChEMBL 36 via Core Engine