Compound Detail
CHEMBL4464030
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CC(c1cn(C)cn1)n1c(NC(C)(C)C)nc2c(-c3cc4c([nH]3)[C@@H](C)NC4=O)cccc2c1=O
Basic Information
| ChEMBL ID | CHEMBL4464030 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ORPVEVRJSBYOAF-KWCCSABGSA-N |
3
Targets
3
Activities
1
Assay Types
2
PK Parameters
5
Publications
0
Known Names
Molecular Properties
459.6
MW (Da)
3.75
ALogP
7
HBA
3
HBD
109.6
PSA (Ų)
0.43
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 9.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | IC50 | 9.92 | 9.92 | 0.1 | 1 |
| Serine/threonine-protein kinase pim-2 CHEMBL4523 | IC50 | 9.15 | 9.15 | 0.7 | 1 |
| Unchecked CHEMBL612545 | IC50 | 7.08 | 7.08 | 83.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| CL | 79.0 | mL.min-1.g-1 | Homo sapiens |
| CL | 63.0 | mL.min-1.g-1 | Rattus norvegicus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | IC50 | = | 0.12 | nM | 9.92 | Inhibition of full length recombinant PIM1 (unknown origin) assessed as reductio... | 30624936 |
| Serine/threonine-protein kinase pim-2 | IC50 | = | 0.7 | nM | 9.15 | Inhibition of full length recombinant PIM2 (unknown origin) assessed as reductio... | 30624936 |
| Unchecked | IC50 | = | 83.0 | nM | 7.08 | Inhibition of PIM1/PIM2/PIM3 in human KMS-12-BM cells assessed as reduction in B... | 30624936 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30624936 | 10.1021/acs.jmedchem.8b01733 | No relevant target | 3 |
| 30624936 | 10.1021/acs.jmedchem.8b01733 | ADMET | 2 |
| 30624936 | 10.1021/acs.jmedchem.8b01733 | Serine/threonine-protein kinase pim-1 | 1 |
| 30624936 | 10.1021/acs.jmedchem.8b01733 | Serine/threonine-protein kinase pim-2 | 1 |
| 30624936 | 10.1021/acs.jmedchem.8b01733 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine