Compound Detail
CHEMBL4465322
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Basic Information
| ChEMBL ID | CHEMBL4465322 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SPZFCJGOBVFLFB-HNNXBMFYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
299.4
MW (Da)
1.64
ALogP
3
HBA
1
HBD
73.2
PSA (Ų)
0.87
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Prolyl endopeptidase CHEMBL2461 | IC50 | 6.66 | 6.66 | 220.0 | 1 |
| Prolyl endopeptidase CHEMBL4935 | IC50 | 6.58 | 6.58 | 264.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Prolyl endopeptidase | IC50 | = | 220.0 | nM | 6.66 | Inhibition of recombinant porcine brain PREP expressed in Escherichia coli asses... | 31857839 |
| Prolyl endopeptidase | IC50 | = | 264.0 | nM | 6.58 | Inhibition of PREP in C57BL/6 mouse cortex homogenate assessed as formation of 7... | 31857839 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31857839 | 10.1021/acsmedchemlett.9b00394 | Prolyl endopeptidase | 4 |
Data from ChEMBL 36 via Core Engine