Compound Detail
CHEMBL4465487
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Basic Information
| ChEMBL ID | CHEMBL4465487 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LPTNDYIJQHJNTF-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
365.7
MW (Da)
4.90
ALogP
4
HBA
1
HBD
51.2
PSA (Ų)
0.74
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 5.58
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein Tat CHEMBL4011 | EC50 | 5.58 | 5.58 | 2600.0 | 1 |
| HEK293 CHEMBL614818 | EC50 | 5.39 | 5.39 | 4100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein Tat | EC50 | = | 2600.0 | nM | 5.58 | Activation of Tat-mediated HIV1 transcription in HEK293- FlpIn-FM cells harborin... | 30973727 |
| HEK293 | EC50 | = | 4100.0 | nM | 5.39 | Activation of non-specific gene expression in HEK293- FlpIn-FM cells harboring L... | 30973727 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30973727 | 10.1021/acs.jmedchem.9b00462 | Protein Tat | 1 |
| 30973727 | 10.1021/acs.jmedchem.9b00462 | HEK293 | 1 |
Data from ChEMBL 36 via Core Engine