Compound Detail
CHEMBL4467732
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Basic Information
| ChEMBL ID | CHEMBL4467732 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NPZGWALWURKYBA-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
317.4
MW (Da)
4.60
ALogP
4
HBA
1
HBD
43.0
PSA (Ų)
0.58
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.32
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Short transient receptor potential channel 5 CHEMBL4523481 | IC50 | 5.32 | 5.32 | 4800.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Short transient receptor potential channel 5 | IC50 | = | 4800.0 | nM | 5.32 | Inhibition of mouse TRPC5 expressed in Flp-In-T-Rex-HEK293 cells assessed as red... | 30538066 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30538066 | 10.1016/j.bmcl.2018.12.007 | Short transient receptor potential channel 5 | 2 |
Data from ChEMBL 36 via Core Engine