Compound Detail
CHEMBL449243
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Basic Information
| ChEMBL ID | CHEMBL449243 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RUQIPEQILCQEGE-UHFFFAOYSA-N |
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
251.1
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 5.48
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| PBMC CHEMBL613107 | IC50 | 5.48 | 5.28 | 3300.0 | 5 |
| Phosphodiesterase 4 CHEMBL2093863 | IC50 | 5.36 | 5.36 | 4400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| PBMC | IC50 | = | 3300.0 | nM | 5.48 | Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglut... | 19303290 |
| PBMC | IC50 | = | 3400.0 | nM | 5.47 | Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglut... | 19303290 |
| Phosphodiesterase 4 | IC50 | = | 4400.0 | nM | 5.36 | Inhibition of PDE4 in human U937 cells assessed as accumulation of [3H]adenosine... | 19303290 |
| PBMC | IC50 | = | 4700.0 | nM | 5.33 | Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglut... | 19303290 |
| PBMC | IC50 | = | 8600.0 | nM | 5.07 | Antiinflammatory activity in human PBMC assessed as inhibition of LPS-induced TN... | 19303290 |
| PBMC | IC50 | = | 8900.0 | nM | 5.05 | Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglut... | 19303290 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19303290 | 10.1016/j.bmcl.2009.03.007 | PBMC | 7 |
| 19303290 | 10.1016/j.bmcl.2009.03.007 | Phosphodiesterase 4 | 1 |
| 19303290 | 10.1016/j.bmcl.2009.03.007 | L929 | 1 |
Data from ChEMBL 36 via Core Engine