Assay Detail
Functional
CHEMBL999435
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Antiinflammatory activity in human PBMC assessed as inhibition of phytohemagglutininin-induced IL10 release after 48 hrs by FACS Array analysis
18
Total Activities
18
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | PBMC |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery and structure-activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 18 | 5.60 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL485359 | — | — | 1 | 6.43 |
| CHEMBL63 | ROLIPRAM | 2.0 | 1 | 6.06 |
| CHEMBL521344 | — | — | 1 | 5.70 |
| CHEMBL484785 | CRISABOROLE | 4.0 | 1 | 5.28 |
| CHEMBL509478 | — | — | 1 | 5.10 |
| CHEMBL449243 | — | — | 1 | 5.05 |
| CHEMBL211300 | — | — | 1 | - |
| CHEMBL520314 | — | — | 1 | - |
| CHEMBL484786 | — | — | 1 | - |
| CHEMBL483990 | — | — | 1 | - |
| CHEMBL485358 | — | — | 1 | - |
| CHEMBL483542 | — | — | 1 | - |
| CHEMBL483339 | — | — | 1 | - |
| CHEMBL485360 | — | — | 1 | - |
| CHEMBL521300 | — | — | 1 | - |
| CHEMBL484171 | — | — | 1 | - |
| CHEMBL452621 | — | — | 1 | - |
| CHEMBL509857 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL485359 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL63 | ROLIPRAM | IC50 | = | 880.0 | nM | 6.06 |
| CHEMBL521344 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL484785 | CRISABOROLE | IC50 | = | 5300.0 | nM | 5.28 |
| CHEMBL509478 | — | IC50 | = | 8000.0 | nM | 5.10 |
| CHEMBL449243 | — | IC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL211300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL520314 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL484786 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL483990 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485358 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL483542 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL483339 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL485360 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL521300 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL484171 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL452621 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL509857 | — | IC50 | > | 10000.0 | nM | - |