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Compound Detail

CHEMBL451043

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O=C(Nc1ccc(C(=O)OCC2CC2)cc1)N[C@@H](Cc1ccc(O)cc1)C(=O)NC1CCN(Cc2ccc(O)cc2)C1

Basic Information

ChEMBL ID CHEMBL451043
Phase Preclinical
Structure Type MOL
InChI Key WUQAXDTXXDUDGH-BTMGADRYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

572.7
MW (Da)
3.79
ALogP
7
HBA
5
HBD
140.2
PSA (Ų)
0.22
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H36N4O6
MW 572.66
Aromatic Rings 3
Heavy Atoms 42
NP-Likeness -1.00

Activity Summary

IC50 3 meas. best 7.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL245
IC50 7.0 7.0 100.0 1
Muscarinic acetylcholine receptor M2
CHEMBL211
IC50 6.4 6.4 398.1 1
Muscarinic acetylcholine receptor M1
CHEMBL216
IC50 6.0 6.0 1000.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18818072 10.1016/j.bmcl.2008.09.020 Muscarinic acetylcholine receptor M2 1
18818072 10.1016/j.bmcl.2008.09.020 Muscarinic acetylcholine receptor M1 1
18818072 10.1016/j.bmcl.2008.09.020 Muscarinic acetylcholine receptor M3 1

Data from ChEMBL 36 via Core Engine