Compound Detail
CHEMBL451174
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Basic Information
| ChEMBL ID | CHEMBL451174 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IVZVLOUIEAWCIN-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
253.3
MW (Da)
3.63
ALogP
2
HBA
1
HBD
38.3
PSA (Ų)
0.84
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 6.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 CHEMBL3229 | IC50 | 6.16 | 6.16 | 691.8 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Fatty-acid amide hydrolase 1 | IC50 | = | 696.0 | nM | 6.16 | Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis | 18507372 |
| Fatty-acid amide hydrolase 1 | IC50 | = | 691.83 | nM | 6.16 | Inhibition of FAAH in rat brain membrane assessed as [3H]anandamide hydrolysis | 18507372 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18507372 | 10.1021/jm701631z | Fatty-acid amide hydrolase 1 | 2 |
Data from ChEMBL 36 via Core Engine