Compound Detail
CHEMBL4529301
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4529301 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UPYOZLWVEBOJPB-UHFFFAOYSA-N |
2
Targets
3
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
398.5
MW (Da)
3.06
ALogP
6
HBA
0
HBD
66.6
PSA (Ų)
0.53
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.82
Ki 1 meas. best 7.88
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| INS1(832/13) CHEMBL4483248 | IC50 | 8.82 | 8.82 | 1.5 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 8.65 | 8.65 | 2.2 | 1 |
| Dipeptidyl peptidase 4 CHEMBL284 | Ki | 7.88 | 7.88 | 13.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| INS1(832/13) | IC50 | = | 1.5 | nM | 8.82 | Antidiabetic activity in glucose-treated rat INS1(832/13) cells assessed as incr... | 31812034 |
| Dipeptidyl peptidase 4 | IC50 | = | 2.25 | nM | 8.65 | Inhibition of human DPP4 in pH 7.4 Tris buffer using AP-7-ATFMC as substrate pre... | 31812034 |
| Dipeptidyl peptidase 4 | Ki | = | 13.07 | nM | 7.88 | Inhibition of human DPP4 | 31812034 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31812034 | 10.1016/j.ejmech.2019.111912 | INS1(832/13) | 5 |
| 31812034 | 10.1016/j.ejmech.2019.111912 | Dipeptidyl peptidase 4 | 3 |
| 31812034 | 10.1016/j.ejmech.2019.111912 | No relevant target | 2 |
Data from ChEMBL 36 via Core Engine