Compound Detail
CHEMBL4532449
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CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(CO[Si](c2ccccc2)(c2ccccc2)C(C)(C)C)CO1
Basic Information
| ChEMBL ID | CHEMBL4532449 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | HOSSAEKKJNDWLK-LKPKVSIJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
974.3
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.95
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 CHEMBL4662 | IC50 | 6.95 | 6.95 | 111.6 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome Macropain subunit MB1 | IC50 | = | 111.6 | nM | 6.95 | Inhibition of 20S proteasome beta5 subunit in human RPMI8226 cell lysate using S... | 30964987 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30964987 | 10.1021/acs.jmedchem.8b01943 | NCI-H23 | 1 |
| 30964987 | 10.1021/acs.jmedchem.8b01943 | NCI-H727 | 1 |
| 30964987 | 10.1021/acs.jmedchem.8b01943 | Proteasome Macropain subunit MB1 | 1 |
Data from ChEMBL 36 via Core Engine