Compound Detail
CHEMBL4532980
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CN1C(=O)CCC(N2Cc3c(C#CCCCCCC(=O)N4CC[C@H]5CC[C@@H](C(=O)N[C@@H](CCC(N)=O)C(=O)NC(c6ccccc6)c6ccccc6)N5C(=O)[C@@H](NC(=O)c5cc6cc(C(F)(F)P(=O)(O)O)ccc6[nH]5)C4)cccc3C2=O)C1=O
Basic Information
| ChEMBL ID | CHEMBL4532980 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | LCEHEBCFBFEIAS-NXYWATGJSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
1172.2
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.28
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Unchecked CHEMBL612545 | IC50 | 5.28 | 5.28 | 5210.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Unchecked | IC50 | = | 5210.0 | nM | 5.28 | Antiproliferative activity against human MOLM16 cells assessed as reduction in c... | 31747516 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Protein cereblon/STAT3 | 7 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Protein cereblon/STAT1 | 2 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Protein cereblon/STAT2 | 2 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Protein cereblon/STAT4 | 2 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Protein cereblon/STAT5A | 2 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Protein cereblon/STAT5B | 2 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Protein cereblon/STAT6 | 2 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | Unchecked | 1 |
| 31747516 | 10.1021/acs.jmedchem.9b01530 | SU-DHL-1 | 1 |
Data from ChEMBL 36 via Core Engine