Compound Detail
CHEMBL453412
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NCCCC[C@@H](C(=O)NCc1ccccc1)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)c2ccc(-c3ccccc3)cc2)C1=O.O=C(O)C(F)(F)F
Basic Information
| ChEMBL ID | CHEMBL453412 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MWTMCVFKRUPDMO-WUVDXXIJSA-N |
| Parent Compound | CHEMBL1186190 |
| Active Moiety | CHEMBL1186190 |
4
Targets
4
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
613.8
MW (Da)
5.33
ALogP
4
HBA
4
HBD
120.3
PSA (Ų)
0.15
QED
2
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.92
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 2 CHEMBL1804 | IC50 | 7.92 | 7.92 | 12.0 | 1 |
| Somatostatin receptor type 5 CHEMBL1792 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | IC50 | 7.27 | 7.27 | 54.0 | 1 |
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 6.79 | 6.79 | 161.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 2 | IC50 | = | 12.0 | nM | 7.92 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
| Somatostatin receptor type 5 | IC50 | = | 16.0 | nM | 7.8 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
| Somatostatin receptor type 3 | IC50 | = | 54.0 | nM | 7.27 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
| Somatostatin receptor type 4 | IC50 | = | 161.0 | nM | 6.79 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 1 | 1 |
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 2 | 1 |
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 3 | 1 |
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 4 | 1 |
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine