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Compound Detail

CHEMBL453575

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CC(C)Cc1cc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)ccc1C(=O)O

Basic Information

ChEMBL ID CHEMBL453575
Phase Preclinical
Structure Type MOL
InChI Key YUPOCJDDQSOMHF-SANMLTNESA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

468.0
MW (Da)
5.61
ALogP
4
HBA
3
HBD
78.8
PSA (Ų)
0.32
QED
1
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C27H30ClNO4
MW 467.99
Aromatic Rings 3
Heavy Atoms 33
NP-Likeness -0.47

Activity Summary

EC50 2 meas. best 9.17

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 9.17 9.17 0.7 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.82 7.82 15.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18553954 10.1021/jm8000345 Beta-3 adrenergic receptor 2
18553954 10.1021/jm8000345 Beta-1 adrenergic receptor 1
18553954 10.1021/jm8000345 Unchecked 1
18553954 10.1021/jm8000345 Canis familiaris 1

Data from ChEMBL 36 via Core Engine