Compound Detail
CHEMBL454202
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
NCCCC[C@@H](C(=O)NCc1ccccc1)N1Cc2[nH]c3ccccc3c2C[C@@H](NC(=O)C2CCN(C(=O)c3ccccc3)CC2)C1=O.O=C(O)C(F)(F)F
Basic Information
| ChEMBL ID | CHEMBL454202 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UAAHGKIBNJJSAH-JVTBPUHLSA-N |
| Parent Compound | CHEMBL1186206 |
| Active Moiety | CHEMBL1186206 |
5
Targets
5
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
648.8
MW (Da)
3.90
ALogP
5
HBA
4
HBD
140.6
PSA (Ų)
0.18
QED
1
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Somatostatin receptor type 5 CHEMBL1792 | IC50 | 8.85 | 8.85 | 1.4 | 1 |
| Somatostatin receptor type 2 CHEMBL1804 | IC50 | 8.68 | 8.68 | 2.1 | 1 |
| Somatostatin receptor type 4 CHEMBL1853 | IC50 | 8.16 | 8.16 | 6.9 | 1 |
| Somatostatin receptor type 1 CHEMBL1917 | IC50 | 7.05 | 7.05 | 89.0 | 1 |
| Somatostatin receptor type 3 CHEMBL2028 | IC50 | 6.92 | 6.92 | 119.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Somatostatin receptor type 5 | IC50 | = | 1.4 | nM | 8.85 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
| Somatostatin receptor type 2 | IC50 | = | 2.1 | nM | 8.68 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
| Somatostatin receptor type 4 | IC50 | = | 6.9 | nM | 8.16 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
| Somatostatin receptor type 1 | IC50 | = | 89.0 | nM | 7.05 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
| Somatostatin receptor type 3 | IC50 | = | 119.0 | nM | 6.92 | Displacement of [125I]-[Leu8, DTrp22, Tyr25]-somatostatin-28 from human recombin... | 19067538 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 1 | 1 |
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 2 | 1 |
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 3 | 1 |
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 4 | 1 |
| 19067538 | 10.1021/jm801205x | Somatostatin receptor type 5 | 1 |
Data from ChEMBL 36 via Core Engine