Compound Detail
CHEMBL4543638
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Basic Information
| ChEMBL ID | CHEMBL4543638 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BLWDTUMJQJGQSU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
373.5
MW (Da)
3.28
ALogP
5
HBA
0
HBD
54.9
PSA (Ų)
0.81
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 8.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M4 CHEMBL1821 | EC50 | 8.05 | 8.05 | 9.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Muscarinic acetylcholine receptor M4 | EC50 | = | 9.0 | nM | 8.05 | Agonist activity at human Muscarinic acetylcholine receptor M4 expressed in HEK ... | 31223452 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31223452 | 10.1021/acsmedchemlett.9b00106 | Muscarinic acetylcholine receptor M4 | 2 |
| 31223452 | 10.1021/acsmedchemlett.9b00106 | Muscarinic acetylcholine receptor M2 | 1 |
Data from ChEMBL 36 via Core Engine