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Compound Detail

CHEMBL454705

ALBANOL A
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CC1=C[C@@H]2c3c(O)cc(-c4cc5ccc(O)cc5o4)cc3O[C@]3(c4ccc(O)cc4O)Oc4cc(O)ccc4[C@@H](C1)C23

Basic Information

ChEMBL ID CHEMBL454705
Name ALBANOL A
Phase Preclinical
Structure Type MOL
InChI Key MJJWBJFYYRAYKU-WLKQUGLZSA-N
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

562.6
MW (Da)
7.10
ALogP
8
HBA
5
HBD
132.8
PSA (Ų)
0.14
QED
2
Ro5 Violations
2
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C34H26O8
MW 562.57
Aromatic Rings 5
Heavy Atoms 42
NP-Likeness 1.82

Activity Summary

IC50 1 meas. best 5.12

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Aromatase
CHEMBL1978
IC50 5.12 5.12 7500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Aromatase IC50 = 7500.0 nM 5.12 Inhibition of aromatase from human placental microsomes 11678652

Literature References

PubMed DOI Target Context # Activities
11678652 10.1021/np010288l Aromatase 1

Data from ChEMBL 36 via Core Engine