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Assay Detail

CHEMBL949646

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of aromatase from human placental microsomes
43
Total Activities
43
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

Aromatase (CHEMBL1978)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Aromatase inhibitors from Broussonetia papyrifera.
Lee D, Bhat KP, Fong HH, Farnsworth NR, Pezzuto JM, Kinghorn AD.
J Nat Prod (2001) 64 : 1286 -1293
PubMed 11678652 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 43 5.41 7.00

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL457679 ISOLICOFLAVONOL 1 7.00
CHEMBL457678 1 7.00
CHEMBL457680 1 6.40
CHEMBL514745 1 6.30
CHEMBL458395 1 5.66
CHEMBL457686 1 5.47
CHEMBL465880 MORACHALCONE A 1 5.34
CHEMBL488 AMINOGLUTETHIMIDE 4.0 1 5.19
CHEMBL463638 ISOGEMICHALCONE C 1 5.15
CHEMBL454705 ALBANOL A 1 5.12
CHEMBL464007 BROUSSOFLAVONOL F 1 5.01
CHEMBL9352 NARINGENIN 1 4.77
CHEMBL458187 1 4.62
CHEMBL465879 BROUSSONIN A 1 4.52
CHEMBL458188 DEMETHYLMORACIN I 1 4.51
CHEMBL465881 MORACIN N 1 4.51
CHEMBL463254 1 -
CHEMBL457261 1 -
CHEMBL457262 1 -
CHEMBL456062 1 -
CHEMBL453448 1 -
CHEMBL457263 1 -
CHEMBL465845 BROUSSONIN F 1 -
CHEMBL165 RESVERATROL 3.0 1 -
CHEMBL442813 MARMESIN 1 -
CHEMBL227113 LOLIOLIDE 1 -
CHEMBL512578 MORACIN M 1 -
CHEMBL463435 MORACIN I 1 -
CHEMBL463241 MORACIN D 1 -
CHEMBL394855 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL457679 ISOLICOFLAVONOL IC50 = 100.0 nM 7.00
CHEMBL457678 IC50 = 100.0 nM 7.00
CHEMBL457680 IC50 = 400.0 nM 6.40
CHEMBL514745 IC50 = 500.0 nM 6.30
CHEMBL458395 IC50 = 2200.0 nM 5.66
CHEMBL457686 IC50 = 3400.0 nM 5.47
CHEMBL465880 MORACHALCONE A IC50 = 4600.0 nM 5.34
CHEMBL488 AMINOGLUTETHIMIDE IC50 = 6400.0 nM 5.19
CHEMBL463638 ISOGEMICHALCONE C IC50 = 7100.0 nM 5.15
CHEMBL454705 ALBANOL A IC50 = 7500.0 nM 5.12
CHEMBL464007 BROUSSOFLAVONOL F IC50 = 9700.0 nM 5.01
CHEMBL9352 NARINGENIN IC50 = 17000.0 nM 4.77
CHEMBL458187 IC50 = 24000.0 nM 4.62
CHEMBL465879 BROUSSONIN A IC50 = 30000.0 nM 4.52
CHEMBL465881 MORACIN N IC50 = 31100.0 nM 4.51
CHEMBL458188 DEMETHYLMORACIN I IC50 = 31100.0 nM 4.51
CHEMBL463255 IC50 > 40.0 ug.mL-1 -
CHEMBL463168 IC50 > 40.0 ug.mL-1 -
CHEMBL463256 IC50 > 40.0 ug.mL-1 -
CHEMBL469444 BAVACHIN IC50 > 40.0 ug.mL-1 -
CHEMBL9323 DIHYDROKAEMPFEROL IC50 > 40.0 ug.mL-1 -
CHEMBL463452 GANCAONIN P IC50 > 40.0 ug.mL-1 -
CHEMBL463453 DIHYDROMORIN IC50 > 40.0 ug.mL-1 -
CHEMBL463454 BROUSSONIN B IC50 > 40.0 ug.mL-1 -
CHEMBL464472 BROUSSONIN E IC50 > 40.0 ug.mL-1 -
CHEMBL465435 IC50 > 40.0 ug.mL-1 -
CHEMBL115452 BROUSSOCHALCONE A IC50 > 40.0 ug.mL-1 -
CHEMBL464428 BROUSSOCHALCONE B IC50 > 40.0 ug.mL-1 -
CHEMBL253467 ISOBAVACHALCONE IC50 > 40.0 ug.mL-1 -
CHEMBL394855 IC50 > 40.0 ug.mL-1 -
CHEMBL463241 MORACIN D IC50 > 40.0 ug.mL-1 -
CHEMBL463435 MORACIN I IC50 > 40.0 ug.mL-1 -
CHEMBL512578 MORACIN M IC50 > 40.0 ug.mL-1 -
CHEMBL227113 LOLIOLIDE IC50 > 40.0 ug.mL-1 -
CHEMBL442813 MARMESIN IC50 > 40.0 ug.mL-1 -
CHEMBL165 RESVERATROL IC50 > 40.0 ug.mL-1 -
CHEMBL465845 BROUSSONIN F IC50 > 40.0 ug.mL-1 -
CHEMBL457263 IC50 > 40.0 ug.mL-1 -
CHEMBL453448 IC50 > 40.0 ug.mL-1 -
CHEMBL456062 IC50 > 40.0 ug.mL-1 -
CHEMBL457262 IC50 > 40.0 ug.mL-1 -
CHEMBL457261 IC50 > 40.0 ug.mL-1 -
CHEMBL463254 IC50 > 40.0 ug.mL-1 -