Compound Detail
CHEMBL463452
GANCAONIN P Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL463452 |
| Name | GANCAONIN P |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OCIIFJFJVOTFTN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
370.4
MW (Da)
3.50
ALogP
7
HBA
5
HBD
131.4
PSA (Ų)
0.35
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.69
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NACHT, LRR and PYD domains-containing protein 3 CHEMBL3779755 | IC50 | 4.69 | 4.69 | 20400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NACHT, LRR and PYD domains-containing protein 3 | IC50 | = | 20400.0 | nM | 4.69 | Inhibition of NLRP3 inflammasome activation in mouse BMDM cells assessed as redu... | 38692522 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 11678652 | 10.1021/np010288l | Aromatase | 1 |
| 38692522 | 10.1016/j.bmcl.2024.129777 | NACHT, LRR and PYD domains-containing protein 3 | 1 |
Data from ChEMBL 36 via Core Engine