Compound Detail
CHEMBL4552527
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL4552527 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KAYDCNXQTQFWMU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
329.8
MW (Da)
3.54
ALogP
4
HBA
1
HBD
68.0
PSA (Ų)
0.79
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Kelch-like ECH-associated protein 1 CHEMBL2069156 | IC50 | 4.36 | 4.36 | 44000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Kelch-like ECH-associated protein 1 | IC50 | = | 44000.0 | nM | 4.36 | Displacement of 5'-TAMRA-labelled NRF2 peptide from human N-terminal His6-tagged... | 30973731 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30973731 | 10.1021/acs.jmedchem.9b00279 | Kelch-like ECH-associated protein 1 | 1 |
Data from ChEMBL 36 via Core Engine