Compound Detail
CHEMBL4556629
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Basic Information
| ChEMBL ID | CHEMBL4556629 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DKLUNKKXISSMIY-KIAYWQFFSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
377.4
MW (Da)
2.59
ALogP
4
HBA
1
HBD
72.5
PSA (Ų)
0.89
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 8.74
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Metabotropic glutamate receptor 7 CHEMBL3966 | EC50 | 8.74 | 8.74 | 1.8 | 1 |
| Metabotropic glutamate receptor 7 CHEMBL3777 | EC50 | 8.16 | 8.16 | 6.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Metabotropic glutamate receptor 7 | EC50 | = | 1.8 | nM | 8.74 | Agonist activity at mouse mGlu7 | 30881607 |
| Metabotropic glutamate receptor 7 | EC50 | = | 6.9 | nM | 8.16 | Agonist activity at human mGlu7 | 30881607 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30881607 | 10.1039/C8MD00524A | Metabotropic glutamate receptor 7 | 2 |
Data from ChEMBL 36 via Core Engine