Compound Detail
CHEMBL4566038
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Basic Information
| ChEMBL ID | CHEMBL4566038 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | DICRWYNNWVSVOE-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
400.4
MW (Da)
3.62
ALogP
6
HBA
1
HBD
93.5
PSA (Ų)
0.51
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein Wnt-3a CHEMBL1255137 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
| Protein-serine O-palmitoleoyltransferase porcupine CHEMBL1255164 | IC50 | 9.7 | 9.7 | 0.2 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein-serine O-palmitoleoyltransferase porcupine | IC50 | = | 0.2 | nM | 9.7 | Inhibition of PORCN in mouse Leydig cells overexpressing Wnt3A co-cultured with ... | 27437076 |
| Protein Wnt-3a | IC50 | = | 0.2 | nM | 9.7 | Wnt-Luc Reporter Assay: Human embryonic kidney 293 cells (obtained from American... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 27437076 | 10.1021/acsmedchemlett.6b00038 | No relevant target | 1 |
| 27437076 | 10.1021/acsmedchemlett.6b00038 | Protein-serine O-palmitoleoyltransferase porcupine | 1 |
Data from ChEMBL 36 via Core Engine