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Target Snapshot

CHEMBL1255137 Target Snapshot

Protein Wnt-3a · SINGLE PROTEIN · Homo sapiens

559Compounds
30Assays
0Approved Drugs
1,077.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P56704. Use UniProt P56704 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P56704 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein Wnt-3a as ChEMBL target CHEMBL1255137, mapped to UniProt P56704. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein Wnt-3a
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL1255137
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P56704
Protein Wnt-3a
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein Wnt-3a is the right protein anchor across sources, using UniProt P56704 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein Wnt-3a
UniProt AccessionP56704
Component TypeProtein
Sequence Length352 aa

Protein Wnt-3a

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Protein Wnt-3a, mapped to UniProt P56704. Sequence length is 352 aa.

Mapped IDP56704
Review nameProtein Wnt-3a
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC501,074.0
KD3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5823795 10.4 IC50 0.04 Preclinical
CHEMBL6039603 10.22 IC50 0.06 Preclinical
CHEMBL5921303 10.15 IC50 0.07 Preclinical
CHEMBL6033847 10.1 IC50 0.08 Preclinical
CHEMBL4532746 10.0 IC50 0.1 Preclinical
CHEMBL4546441 10.0 IC50 0.1 Preclinical
CHEMBL5759987 10.0 IC50 0.1 Preclinical
CHEMBL5760694 10.0 IC50 0.1 Preclinical
CHEMBL5761075 10.0 IC50 0.1 Preclinical
CHEMBL5785948 10.0 IC50 0.1 Preclinical
Distribution

pChEMBL Value Distribution

66
5.0
46
5.5
96
6.0
131
6.5
118
7.0
83
7.5
59
8.0
42
8.5
42
9.0
36
9.5
pChEMBL
Assay Landscape

Assay Landscape

30
Total Assays
533
Tested Compounds
1
Assay Types
Binding — 30 assays, 533 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 20 272 8.2
assay format 7 258 6.5
single protein format 3 3 4.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine