Compound Detail
CHEMBL5760694
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CC(=O)N1CCN(c2ccc(NC(=O)Cc3cnc(-c4ccnc(C)c4)c(C(F)(F)F)c3)nc2)CC1
Basic Information
| ChEMBL ID | CHEMBL5760694 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FJFWSYCGKKNLDD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
498.5
MW (Da)
3.72
ALogP
6
HBA
1
HBD
91.3
PSA (Ų)
0.58
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 10.0
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein Wnt-3a CHEMBL1255137 | IC50 | 10.0 | 10.0 | 0.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein Wnt-3a | IC50 | = | 0.1 | nM | 10.0 | Wnt-Luc Reporter Assay: Human embryonic kidney 293 cells (obtained from American... | - |
Data from ChEMBL 36 via Core Engine