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Compound Detail

CHEMBL4574497

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CCCCCCC(C)(C)c1cc(OCCCBr)c2c(c1)OC(C)(C)c1cn(C)nc1-2

Basic Information

ChEMBL ID CHEMBL4574497
Phase Preclinical
Structure Type MOL
InChI Key YYPKRSZPIRSYDL-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

477.5
MW (Da)
7.13
ALogP
4
HBA
0
HBD
36.3
PSA (Ų)
0.27
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H37BrN2O2
MW 477.49
Aromatic Rings 2
Heavy Atoms 30
NP-Likeness 0.08

Activity Summary

Ki 2 meas. best 7.11

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Cannabinoid receptor 2
CHEMBL253
Ki 7.11 7.11 77.3 1
Cannabinoid receptor 1
CHEMBL218
Ki 5.83 5.83 1482.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
27309150 10.1021/acs.jmedchem.6b00397 Cannabinoid receptor 2 3
27309150 10.1021/acs.jmedchem.6b00397 Unchecked 2
27309150 10.1021/acs.jmedchem.6b00397 Cannabinoid receptor 1 1
27309150 10.1021/acs.jmedchem.6b00397 Albumin 1

Data from ChEMBL 36 via Core Engine