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Compound Detail

CHEMBL4579076

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O=C(Nc1cccc(F)n1)c1cn2cc(-c3ccccn3)ccc2n1

Basic Information

ChEMBL ID CHEMBL4579076
Phase Preclinical
Structure Type MOL
InChI Key CHYWJGJBXBECDR-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names

Molecular Properties

333.3
MW (Da)
3.18
ALogP
5
HBA
1
HBD
72.2
PSA (Ų)
0.58
QED
0
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C18H12FN5O
MW 333.33
Aromatic Rings 4
Heavy Atoms 25
NP-Likeness -2.27

Activity Summary

EC50 2 meas. best 9.22

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Nuclear receptor subfamily 4 group A member 2
CHEMBL3879839
EC50 9.22 9.22 0.6 1
Nuclear receptor subfamily 4 group A member 2
CHEMBL5002
EC50 7.6 7.6 25.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
30773432 10.1016/j.bmcl.2019.01.024 Nuclear receptor subfamily 4 group A member 2 4

Data from ChEMBL 36 via Core Engine