Assay Detail
Binding
CHEMBL4370880
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at Nurr1 in mouse N2A cells harboring NBRE by luciferase reporter gene assay
34
Total Activities
17
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Mus musculus |
| Cell Type | N2a |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Nuclear receptor subfamily 4 group A member 2 (CHEMBL3879839) ↗| Type | SINGLE PROTEIN |
| Organism | Mus musculus |
Publication
Development of a novel NURR1/NOT agonist from hit to lead and candidate for the potential treatment of Parkinson's disease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Emax | 17 | - | - |
| EC50 | 17 | 8.38 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4579076 | — | — | 2 | 9.22 |
| CHEMBL4435806 | — | — | 2 | 9.10 |
| CHEMBL4472621 | — | — | 2 | 9.00 |
| CHEMBL4576867 | — | — | 2 | 9.00 |
| CHEMBL4542579 | — | — | 2 | 9.00 |
| CHEMBL4453191 | — | — | 2 | 9.00 |
| CHEMBL4516628 | — | — | 2 | 9.00 |
| CHEMBL4440924 | — | — | 2 | 9.00 |
| CHEMBL4475835 | — | — | 2 | 8.92 |
| CHEMBL4455780 | — | — | 2 | 8.70 |
| CHEMBL4464547 | — | — | 2 | 8.60 |
| CHEMBL4450849 | — | — | 2 | 7.70 |
| CHEMBL4465777 | — | — | 2 | 7.68 |
| CHEMBL4528015 | — | — | 2 | 7.58 |
| CHEMBL4521080 | — | — | 2 | 7.26 |
| CHEMBL4454933 | — | — | 2 | 7.17 |
| CHEMBL4473547 | — | — | 2 | 6.54 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4579076 | — | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL4435806 | — | EC50 | = | 0.8 | nM | 9.10 |
| CHEMBL4472621 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4576867 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4440924 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4516628 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4453191 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4542579 | — | EC50 | = | 1.0 | nM | 9.00 |
| CHEMBL4475835 | — | EC50 | = | 1.2 | nM | 8.92 |
| CHEMBL4455780 | — | EC50 | = | 2.0 | nM | 8.70 |
| CHEMBL4464547 | — | EC50 | = | 2.5 | nM | 8.60 |
| CHEMBL4450849 | — | EC50 | = | 20.0 | nM | 7.70 |
| CHEMBL4465777 | — | EC50 | = | 21.0 | nM | 7.68 |
| CHEMBL4528015 | — | EC50 | = | 26.5 | nM | 7.58 |
| CHEMBL4521080 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL4454933 | — | EC50 | = | 67.6 | nM | 7.17 |
| CHEMBL4473547 | — | EC50 | = | 292.0 | nM | 6.54 |
| CHEMBL4473547 | — | Emax | = | 52.0 | % | - |
| CHEMBL4475835 | — | Emax | = | 64.0 | % | - |
| CHEMBL4579076 | — | Emax | = | 86.0 | % | - |
| CHEMBL4453191 | — | Emax | = | 68.0 | % | - |
| CHEMBL4542579 | — | Emax | = | 85.0 | % | - |
| CHEMBL4516628 | — | Emax | = | 104.0 | % | - |
| CHEMBL4435806 | — | Emax | = | 72.0 | % | - |
| CHEMBL4440924 | — | Emax | = | 103.0 | % | - |
| CHEMBL4450849 | — | Emax | = | 62.0 | % | - |
| CHEMBL4528015 | — | Emax | = | 68.0 | % | - |
| CHEMBL4464547 | — | Emax | = | 85.0 | % | - |
| CHEMBL4454933 | — | Emax | = | 70.0 | % | - |
| CHEMBL4576867 | — | Emax | = | 240.0 | % | - |
| CHEMBL4465777 | — | Emax | = | 61.0 | % | - |
| CHEMBL4472621 | — | Emax | = | 204.0 | % | - |
| CHEMBL4455780 | — | Emax | = | 87.0 | % | - |
| CHEMBL4521080 | — | Emax | = | 85.0 | % | - |