Compound Detail
CHEMBL4587118
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Basic Information
| ChEMBL ID | CHEMBL4587118 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | WASHBTYJUCCBAU-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names
Molecular Properties
449.5
MW (Da)
3.66
ALogP
7
HBA
1
HBD
80.9
PSA (Ų)
0.50
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 9.46
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 1 CHEMBL4040 | IC50 | 9.46 | 9.46 | 0.3 | 1 |
| Mitogen-activated protein kinase; ERK1/ERK2 CHEMBL1907606 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 1 | IC50 | = | 0.35 | nM | 9.46 | Inhibition of MEK U911-activated ERK2 (unknown origin) using ERKtide as substrat... | 31710489 |
| Mitogen-activated protein kinase; ERK1/ERK2 | IC50 | = | 20.0 | nM | 7.7 | Inhibition of ERK1/2 in human A375 cells assessed as inhibition of RSK phosphory... | 31710489 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31710489 | 10.1021/acs.jmedchem.9b01295 | ADMET | 4 |
| 31710489 | 10.1021/acs.jmedchem.9b01295 | Mitogen-activated protein kinase 1 | 2 |
| 31710489 | 10.1021/acs.jmedchem.9b01295 | Mitogen-activated protein kinase; ERK1/ERK2 | 2 |
| 31710489 | 10.1021/acs.jmedchem.9b01295 | No relevant target | 2 |
| 31710489 | 10.1021/acs.jmedchem.9b01295 | Voltage-gated inwardly rectifying potassium channel KCNH2 | 1 |
Data from ChEMBL 36 via Core Engine