Compound Detail
CHEMBL4593539
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Basic Information
| ChEMBL ID | CHEMBL4593539 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FVAALOCLUOICNG-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
468.6
MW (Da)
3.54
ALogP
8
HBA
5
HBD
115.9
PSA (Ų)
0.27
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 8.15
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 CHEMBL260 | IC50 | 8.15 | 8.15 | 7.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase 14 | IC50 | = | 7.0 | nM | 8.15 | Inhibition of P38alpha MAPK (unknown origin) | 31445234 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31445234 | 10.1016/j.ejmech.2019.111624 | Mitogen-activated protein kinase 14 | 1 |
Data from ChEMBL 36 via Core Engine