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Compound Detail

CHEMBL4594273

ELACESTRANT HYDROCHLORIDE
💊 Approved Drug
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💊 Approved Drug
CCNCCc1ccc(CN(CC)c2cc(OC)ccc2[C@@H]2CCc3cc(O)ccc3C2)cc1.Cl.Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4594273
Name ELACESTRANT HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key XGFHYCAZOCBCRQ-FBHGDYMESA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL4297509
Active Moiety CHEMBL4297509

Known Names

Elacestrant dihydrochloride Elacestrant hydrochloride Orserdu RAD-1901 DIHYDROCHLORIDE RAD1901 DIHYDROCHLORIDE RAD1901 hydrochloride
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
6
Known Names
3
Indications
1
Mechanisms

Molecular Properties

458.6
MW (Da)
5.85
ALogP
4
HBA
2
HBD
44.7
PSA (Ų)
0.37
QED
1
Ro5 Violations
10
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2023
Availability Prescription
Chirality Single Enantiomer

Routes of Administration

Oral
USAN Stem -estr-; -estrant
USAN Year 2019

Extended Properties

Molecular Formula C30H40Cl2N2O2
MW 531.57
Aromatic Rings 3
Heavy Atoms 34
NP-Likeness -0.05

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Estrogen receptor alpha degrader DEGRADER Estrogen receptor ✓ ✓

Indications

Breast Neoplasms Breast Neoplasms, Male Liver Diseases

Data from ChEMBL 36 via Core Engine