Compound Detail
CHEMBL460842
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Basic Information
| ChEMBL ID | CHEMBL460842 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PDSFQJYJMMJUTN-IXUJDMMCSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
306.2
MW (Da)
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 CHEMBL284 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Prolyl endopeptidase FAP CHEMBL4683 | IC50 | 7.34 | 7.34 | 46.0 | 1 |
| Dipeptidyl peptidase 2 CHEMBL3976 | IC50 | 6.38 | 6.38 | 420.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dipeptidyl peptidase 4 | IC50 | = | 8.0 | nM | 8.1 | Inhibition of DPP4 | 19217790 |
| Prolyl endopeptidase FAP | IC50 | = | 46.0 | nM | 7.34 | Inhibition of FAP | 19217790 |
| Dipeptidyl peptidase 2 | IC50 | = | 420.0 | nM | 6.38 | Inhibition of DPP7 | 19217790 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19217790 | 10.1016/j.bmc.2009.01.061 | Dipeptidyl peptidase 4 | 1 |
| 19217790 | 10.1016/j.bmc.2009.01.061 | Prolyl endopeptidase FAP | 1 |
| 19217790 | 10.1016/j.bmc.2009.01.061 | Dipeptidyl peptidase 2 | 1 |
Data from ChEMBL 36 via Core Engine