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Compound Detail

CHEMBL461301

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O=C(O)c1ccc(-c2ccc(OCCNC[C@H](O)c3cccc(Cl)c3)cc2)cc1OC1CCCCC1

Basic Information

ChEMBL ID CHEMBL461301
Phase Preclinical
Structure Type MOL
InChI Key IIDUXNTUNDZZQP-MHZLTWQESA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
4
Publications
0
Known Names

Molecular Properties

510.0
MW (Da)
6.12
ALogP
5
HBA
3
HBD
88.0
PSA (Ų)
0.27
QED
2
Ro5 Violations
11
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C29H32ClNO5
MW 510.03
Aromatic Rings 3
Heavy Atoms 36
NP-Likeness -0.43

Activity Summary

EC50 2 meas. best 9.57

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Beta-3 adrenergic receptor
CHEMBL246
EC50 9.57 9.57 0.3 1
Beta-1 adrenergic receptor
CHEMBL213
EC50 7.28 7.28 52.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
18553954 10.1021/jm8000345 Beta-3 adrenergic receptor 2
18553954 10.1021/jm8000345 Beta-1 adrenergic receptor 1
18553954 10.1021/jm8000345 Unchecked 1
18553954 10.1021/jm8000345 Canis familiaris 1

Data from ChEMBL 36 via Core Engine