Compound Detail
CHEMBL4633830
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Basic Information
| ChEMBL ID | CHEMBL4633830 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CHBHVUZVWJUTBN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
251.7
MW (Da)
1.89
ALogP
4
HBA
1
HBD
41.3
PSA (Ų)
0.89
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 2.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Son of sevenless homolog 1 CHEMBL2079846 | Kd | 2.72 | 2.72 | 1900000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Son of sevenless homolog 1 | Kd | = | 1900000.0 | nM | 2.72 | Binding affinity to IVLM methyl-labeled SOS1 catalytic domain (566 to 1046 resid... | 32673492 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32673492 | 10.1021/acs.jmedchem.0c00511 | Son of sevenless homolog 1 | 1 |
Data from ChEMBL 36 via Core Engine