Assay Detail
Binding
CHEMBL4621788
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Binding affinity to IVLM methyl-labeled SOS1 catalytic domain (566 to 1046 residues) (unknown origin) by 1H-13C HMQC NMR analysis
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Sulfonamide-Derived Agonists of SOS1-Mediated Nucleotide Exchange on RAS Using Fragment-Based Methods.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 3.58 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4214821 | — | — | 1 | 6.85 |
| CHEMBL1194871 | — | — | 1 | 3.48 |
| CHEMBL1314048 | — | — | 1 | 3.46 |
| CHEMBL4641882 | — | — | 1 | 3.22 |
| CHEMBL4647648 | — | — | 1 | 3.14 |
| CHEMBL4635871 | — | — | 1 | 2.92 |
| CHEMBL4637977 | — | — | 1 | 2.85 |
| CHEMBL4633830 | — | — | 1 | 2.72 |
| CHEMBL4644614 | — | — | 1 | - |
| CHEMBL4637606 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4214821 | — | Kd | = | 140.0 | nM | 6.85 |
| CHEMBL1194871 | — | Kd | = | 330000.0 | nM | 3.48 |
| CHEMBL1314048 | — | Kd | = | 350000.0 | nM | 3.46 |
| CHEMBL4641882 | — | Kd | = | 600000.0 | nM | 3.22 |
| CHEMBL4647648 | — | Kd | = | 730000.0 | nM | 3.14 |
| CHEMBL4635871 | — | Kd | = | 1200000.0 | nM | 2.92 |
| CHEMBL4637977 | — | Kd | = | 1400000.0 | nM | 2.85 |
| CHEMBL4633830 | — | Kd | = | 1900000.0 | nM | 2.72 |
| CHEMBL4644614 | — | Kd | > | 2000000.0 | nM | - |
| CHEMBL4637606 | — | Kd | > | 2000000.0 | nM | - |