Compound Detail
CHEMBL4635496
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Basic Information
| ChEMBL ID | CHEMBL4635496 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PMWIFIWWNULSSP-SNAWJCMRSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
437.5
MW (Da)
3.06
ALogP
6
HBA
1
HBD
85.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 2 meas. best 8.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bromodomain-containing protein 9 CHEMBL3108640 | Kd | 8.7 | 8.7 | 2.0 | 1 |
| Bromodomain-containing protein 7 CHEMBL3085622 | Kd | 7.0 | 7.0 | 100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bromodomain-containing protein 9 | Kd | = | 1.995 | nM | 8.7 | Binding affinity to BRD9 (unknown origin) | 32410449 |
| Bromodomain-containing protein 7 | Kd | = | 100.0 | nM | 7.0 | Binding affinity to BRD7 (unknown origin) | 32410449 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32410449 | 10.1021/acs.jmedchem.0c00075 | Bromodomain-containing protein 7 | 1 |
| 32410449 | 10.1021/acs.jmedchem.0c00075 | Bromodomain-containing protein 9 | 1 |
Data from ChEMBL 36 via Core Engine