Compound Detail
CHEMBL4636726
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Basic Information
| ChEMBL ID | CHEMBL4636726 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MPBOXCMUQRNTQF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
220.3
MW (Da)
2.29
ALogP
4
HBA
1
HBD
41.0
PSA (Ų)
0.85
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.3
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 CHEMBL2148 | IC50 | 5.3 | 5.3 | 5000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Tyrosine-protein kinase JAK3 | IC50 | = | 5000.0 | nM | 5.3 | Inhibition of human JAK3 (780 to end residues) expressed in baculovirus infected... | 32511913 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32511913 | 10.1021/acs.jmedchem.0c00450 | Tyrosine-protein kinase JAK3 | 1 |
| 32511913 | 10.1021/acs.jmedchem.0c00450 | Tyrosine-protein kinase Lck | 1 |
Data from ChEMBL 36 via Core Engine