Compound Detail
CHEMBL4638490
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Basic Information
| ChEMBL ID | CHEMBL4638490 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MCTLSQYQBQKNRU-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
1.54
ALogP
5
HBA
2
HBD
92.3
PSA (Ų)
0.86
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Kd 1 meas. best 4.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| TAR DNA-binding protein 43 CHEMBL2362981 | Kd | 4.05 | 4.05 | 89000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| TAR DNA-binding protein 43 | Kd | = | 89000.0 | nM | 4.05 | Binding affinity to TDP-43 (unknown origin) | 31926785 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31926785 | 10.1016/j.bmcl.2019.126942 | TAR DNA-binding protein 43 | 1 |
Data from ChEMBL 36 via Core Engine