Compound Detail
CHEMBL46435
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Basic Information
| ChEMBL ID | CHEMBL46435 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VSQZHHMCQTVPFR-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
427.3
MW (Da)
5.71
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.53
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 5.26
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ATP-sensitive inward rectifier potassium channel 11 CHEMBL1886 | EC50 | 5.26 | 5.26 | 5550.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ATP-sensitive inward rectifier potassium channel 11 | EC50 | = | 5550.0 | nM | 5.26 | Potassium channel opening activity in vitro using LtK cells transfected with Kir... | 12729655 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12729655 | 10.1016/s0960-894x(03)00205-1 | ATP-sensitive inward rectifier potassium channel 11 | 1 |
Data from ChEMBL 36 via Core Engine